Blar i forfatter "Mortensen, Elin Synnøve"

Viser treff 1-13 av 13

    • Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life study 

      Lofterød, Trygve; Frydenberg, Hanne; Flote, Vidar Gordon; Eggen, Anne Elise; McTiernan, A; Mortensen, Elin Synnøve; Akslen, Lars A.; Reitan, J. B.; Wilsgaard, Tom; Inger, Thune (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-20)
      <i>Purpose</i> - Whether an unfavorable lifestyle not only affects breast cancer risk, but also influences age at onset of breast cancer and survival, is under debate.<br><br> <i>Methods</i> - In a population-based cohort, the Energy Balance and Breast Cancer Aspects throughout life (EBBA-Life) study, a total of 17,145 women were included. During follow-up, 574 women developed invasive breast cancer. ...

    • The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers 

      Knutsen, Erik; Lellahi, Seyed Mohammad; Aure, Miriam Ragle; Nord, Silje; Fismen, Silje; Larsen, Kenneth Bowitz; Tellez Gabriel, Marta; Hedberg, Annica; Bjørklund, Sunniva; Bofin, Anna M.; Mælandsmo, Gunhild Mari; Sørlie, Therese; Mortensen, Elin Synnøve; Perander, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-28)
      The long non-coding RNA <i>NEAT1</i> locus is transcribed into two overlapping isoforms, <i>NEAT1_1</i> and <i>NEAT1_2</i>, of which the latter is essential for the assembly of nuclear paraspeckles. <i>NEAT1</i> is abnormally expressed in a wide variety of human cancers. Emerging evidence suggests that the two isoforms have distinct functions in gene expression regulation, and recently it was shown ...

    • HPV E6/E7 mRNA Testing Is More Specific than Cytology in Post-Colposcopy Follow-Up of Women with Negative Cervical Biopsy 

      Sørbye, Sveinung Wergeland; Arbyn, Marc; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      In Norway, women with negative or low-grade cervical biopsies (normal/CIN1) are followed up after six months in order to decide on further follow-up or recall for screening at three-year intervals. A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures whereas a low risk of high-grade disease among triage ...

    • HPV mRNA is more specific than HPV DNA in triage of women with minor cervical lesions 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-18)
      311 women were scheduled for triage of minor cervical lesions (ASC-US / LSIL). 30 women (9.6%) had ASC-H/HSIL cytology at triage and 281 women (90.4%) had ASC-US/LSIL or normal cytology. The HPV DNA test was positive in 92 (32.7%) of 281 instances, and 37 (13.2%) were mRNA positive. Of the 132 women with repeated ASC-US/LSIL, we received biopsies from 97.0% (65/67) of the DNA-positive and 92.9% ...

    • HPV mRNA test in primry screening of women 20-34 years 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Conference object; Konferansebidrag, 2011)

    • HPV mRNA testing in triage of women with ASC-US cytology may reduce the time for CIN2+ diagnosis compared with repeat cytology. 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: In delayed HPV triage women with atypical squamous cells of uncertain significance (ASC-US) cytology are retested after 6-12 months in order to decide whether they should be referred for colposcopy, further follow-up cytology or routine screening in three years. Triage using a specific HPV E6/E7 mRNA test may reduce referrals for colposcopy of women with ASC-US cytology compared to HPV ...

    • ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes 

      Figenschau, Stine; Knutsen, Erik; Urbarova, Ilona; Fenton, Christopher Graham; Elston, Bryan; Perander, Maria; Mortensen, Elin Synnøve; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-06)
      Intratumoral formation of tertiary lymphoid structures (TLS) within the tumor microenvironment is considered to be a consequence of antigen challenge during anti-tumor responses. Intracellular adhesion molecule 1 (ICAM1) has been implicated in a variety of immune and inflammatory responses, in addition to associate with triple negative breast cancer (TNBC). In this study, we detected TLS in the ...

    • Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes 

      Lofterød, Trygve; Mortensen, Elin Synnøve; Nalwoga, Hawa; Wilsgaard, Tom; Frydenberg, Hanne; Risberg, Terje; Eggen, Anne Elise; McTiernan, Anne; Aziz, Sura Mohammed; Wist, Erik; Stensvold, Andreas; Reitan, Jon Brinchmann; Akslen, Lars A.; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-15)
      <i>Background</i>: High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains unclear.<p> <p><i>Methods</i>: A population-based survival study among 464 breast cancer cases ...

    • Lupus Nephritis: Enigmas, Conflicting Models and an Emerging Concept 

      Seredkina, Natalya; van der Vlag, Johan; Berden, Jo; Mortensen, Elin Synnøve; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Autoantibodies to components of chromatin, which include double-stranded DNA (dsDNA), histones and nucleosomes, are central in the pathogenesis of lupus nephritis. How anti-chromatin autoantibodies exert their nephritogenic activity, however, is controversial. One model assumes that autoantibodies initiate inflammation when they cross-react with intrinsic glomerular structures such as components ...

    • Primary cervical cancer screening with an HPV mRNA test: a prospective cohort study 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-11)
      <b>Objectives</b> To assess the performance of a 5-type human papillomavirus (HPV) messenger RNA (mRNA) test in primary screening within the framework of the Norwegian population-based screening programme. <br> <b>Design</b> Nationwide register-based cohort study. <br> <b>Setting</b> In 2003–2004, general practitioners and gynaecologists recruited 18 852 women for participation in a primary ...

    • Redegjør for HPV-resultater 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve (Chronicle; Kronikk, 2011-01-25)
      Fire Tromsø-leger tilbakeviser kritikk fra Bergen-professor om at de har oversolgt resultater fra sin studie om HPV-testing. De redegjør for hvordan de har fulgt opp kvinner med usikre celleforandringer.

    • Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e 

      Thiyagarajan, Dhivya; Fismen, Silje; Seredkina, Natalya; Jacobsen, Søren; Elung-Jensen, Thomas; Kamper, Anne-Lise; Fenton, Christopher Graham; Rekvig, Ole Petter; Mortensen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Recent studies demonstrate that transformation of mild lupus nephritis into end-stage disease is imposed by silencing of renal DNaseI gene expression in (NZBxNZW)F1 mice. Down-regulation of DNaseI results in reduced chromatin fragmentation, and in deposition of extracellular chromatin-IgG complexes in glomerular basement membranes in individuals that produce IgG anti-chromatin antibodies. The main ...

    • Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients 

      Figenschau, Stine Linn; Fismen, Silje; Fenton, Kristin Andreassen; Fenton, Christopher Graham; Mortensen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-06)
      Background: Tertiary lymphoid structures (TLS) are highly organized immune cell aggregates that develop at sites of inflammation or infection in non-lymphoid organs. Despite the described role of inflammation in tumor progression, it is still unclear whether the process of lymphoid neogenesis and biological function of ectopic lymphoid tissue in tumors are beneficial or detrimental to tumor growth. ...